An observational study of response heterogeneity in children with attention deficit hyperactivity disorder following treatment switch to modified-release methylphenidate

Table 3 Results of multinomial logistic regression with latent class as criterion

	High-start, mixed response vs. low-start, low response		High-start, first-phase response vs. low-start, low response		High-start, low-response vs. low-start, low response		High-start, mixed response vs. high-start, low response		High-start, first-phase response vs. high-start, low response		High-start, mixed response vs. high-start, first-phase response
	β	OR	β	OR	β	OR	β	OR	β	OR	β	OR
Age (years)	–0.85^a	0.43	–0.65^a	0.52	–0.39^a	0.68	–0.46	0.63	–0.26	0.77	–0.20	0.82
MPH_pre (mg)	–1.18^a	0.31	–0.73^a	0.48	0.11	1.12	–1.29^a	0.28	–0.84^a	0.43	–0.46	0.63
MPH_{Visit 1} (mg)	–0.13	0.88	0.03	1.03	–0.15	0.87	0.02	1.02	0.18	1.19	–0.16	0.85
MPH_{Visit 2} (mg)	–0.07	0.94	–0.02	0.98	0.06	1.06	–0.12	0.88	–0.08	0.92	–0.04	0.96
Conduct problems^b	2.80^a	16.40	1.93^a	6.92	1.60^a	4.97	1.19^a	3.29	0.33	1.39	0.87^a	2.38
Emotional symptoms^c	–0.31	0.73	–0.26	0.77	0.17	1.18	–0.48	0.62	–0.42	0.66	–0.06	0.95

High-start = subgroups with more severe symptoms compared with the low-start group at Visit 1; mixed-response = in parent ratings, comparatively stronger treatment response is observed during Visit 2 to Visit 3 and in teacher rating during Visit 1 to Visit 2; first-phase response = in parent and in teacher ratings comparatively stronger treatment response is observed during Visit 1 to Visit 2; low-response = compared with other subgroups only minor symptom reduction is detected during the observational period; for analyses, all covariates were z-transformed.
β = regression coefficient; OR = odds ratio; MPH = methylphenidate; MPH_pre = daily dose of MPH before switch to modified-release MPH; MPH_{Visit 1} = daily dose of modified-release MPH prescribed at Visit 1; MPH_{Visit 2} = daily dose of modified-release MPH prescribed at Visit 2.
^aα < 0.05.
^bConduct Problems Scale Strengths and Difficulties Questionnaire in parent ratings at Visit 1.
^cEmotional Symptoms Scale Strengths and Difficulties Questionnaire in parent ratings at Visit 1.

ISSN: 1471-244X