| Placebo | Olanzapine | p Value | ||
---|---|---|---|---|---|
 | n | LS mean (SE) | n | LS mean (SE) |  |
Weight gain, kg | 52 | −0.36 (0.29) | 104 | +2.12 (0.21) | <.001 |
 |  | n/N (%) |  | n/N (%) |  |
Patients with significant weight gain (≥7% body weight) |  | 1/52 (1.9) |  | 21/104 (20.2) | .001 |
 | n | LS mean (SE) | n | LS mean (SE) |  |
Baseline-to-endpoint change in fasting laboratory values | Â | Â | Â | Â | Â |
 Cholesterol, mg/dL | 52 | −0.96 (3.37) | 104 | +10.06 (2.38) | .008 |
 Triglycerides, mg/dL | 52 | −4.17 (12.31) | 104 | +30.67 (8.68) | .02 |
 LDL, mg/dL | 51 | −1.06 (3.07) | 103 | +8.78 (2.16) | .01 |
 HDL, mg/dL | 52 | +1.10 (1.27) | 104 | −2.99 (0.90) | .01 |
 Glucose, mg/dL | 51 | −1.02 (1.11) | 100 | + 1.01 (0.79) | .14 |
 |  | n/N (%) |  | n/N (%) |  |
Patients with categorical shifts in fasting cholesterol values | Â | Â | Â | Â | Â |
 Normal to borderline |  | 2/17 (11.8) |  | 13/39 (33.3) | .11 |
 Normal to high |  | 0/17 (0.0) |  | 1/39 (2.6) | 1.00 |
 Borderline to high |  | 0/25 (0.0) |  | 13/52 (25.0) | .007 |
Patients with categorical shifts in fasting triglyceride values | Â | Â | Â | Â | Â |
 Normal to borderline |  | 3/37 (8.1) |  | 5/82 (6.1) | .70 |
 Normal to high |  | 1/37 (2.7) |  | 9/82 (11.0) | .17 |
 Normal to extremely high |  | 0/37 (0.0) |  | 0/82 (0.0) | -- |
 Borderline to high |  | 1/9 (11.1) |  | 3/12 (25.0) | .60 |
 Borderline to extremely high |  | 0/9 (0.0) |  | 0/12 (0.0) | -- |
Patients with categorical shifts in fasting LDL cholesterol values | Â | Â | Â | Â | Â |
 Normal to borderline |  | 4/9 (44.4) |  | 11/26 (42.3) | >.99 |
 Normal to high |  | 0/9 (0.0) |  | 0/26 (0.0) | -- |
 Borderline to high |  | 0/34 (0.0) |  | 6/68 (8.8) | .18 |
Patients with categorical shifts in fasting HDL cholesterol values | Â | Â | Â | Â | Â |
 Normal to low |  | 0/46 (0.0) |  | 8/97 (8.2) | .05 |
Patients with categorical shifts in fasting glucose values | Â | Â | Â | Â | Â |
 Normal to impaired |  | 5/32 (15.6) |  | 9/72 (12.5) | .76 |
 Impaired to high |  | 0/18 (0.0) |  | 2/28 (7.1) | .51 |
 Normal/impaired to high |  | 0/50 (0.0) |  | 3/100 (3.0) | .55 |
 Normal to high |  | 0/32 (0.0) |  | 1/72 (1.4) | 1.00 |