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Table 5 Absolute and categorical changes in weight, total cholesterol, triglycerides, LDL, HDL, and glucose

From: Efficacy and safety of olanzapine for treatment of patients with bipolar depression: Japanese subpopulation analysis of a randomized, double-blind, placebo-controlled study

 

Placebo

Olanzapine

p Value

 

n

LS mean (SE)

n

LS mean (SE)

 

Weight gain, kg

52

−0.36 (0.29)

104

+2.12 (0.21)

<.001

  

n/N (%)

 

n/N (%)

 

Patients with significant weight gain (≥7% body weight)

 

1/52 (1.9)

 

21/104 (20.2)

.001

 

n

LS mean (SE)

n

LS mean (SE)

 

Baseline-to-endpoint change in fasting laboratory values

     

 Cholesterol, mg/dL

52

−0.96 (3.37)

104

+10.06 (2.38)

.008

 Triglycerides, mg/dL

52

−4.17 (12.31)

104

+30.67 (8.68)

.02

 LDL, mg/dL

51

−1.06 (3.07)

103

+8.78 (2.16)

.01

 HDL, mg/dL

52

+1.10 (1.27)

104

−2.99 (0.90)

.01

 Glucose, mg/dL

51

−1.02 (1.11)

100

+ 1.01 (0.79)

.14

  

n/N (%)

 

n/N (%)

 

Patients with categorical shifts in fasting cholesterol values

     

 Normal to borderline

 

2/17 (11.8)

 

13/39 (33.3)

.11

 Normal to high

 

0/17 (0.0)

 

1/39 (2.6)

1.00

 Borderline to high

 

0/25 (0.0)

 

13/52 (25.0)

.007

Patients with categorical shifts in fasting triglyceride values

     

 Normal to borderline

 

3/37 (8.1)

 

5/82 (6.1)

.70

 Normal to high

 

1/37 (2.7)

 

9/82 (11.0)

.17

 Normal to extremely high

 

0/37 (0.0)

 

0/82 (0.0)

--

 Borderline to high

 

1/9 (11.1)

 

3/12 (25.0)

.60

 Borderline to extremely high

 

0/9 (0.0)

 

0/12 (0.0)

--

Patients with categorical shifts in fasting LDL cholesterol values

     

 Normal to borderline

 

4/9 (44.4)

 

11/26 (42.3)

>.99

 Normal to high

 

0/9 (0.0)

 

0/26 (0.0)

--

 Borderline to high

 

0/34 (0.0)

 

6/68 (8.8)

.18

Patients with categorical shifts in fasting HDL cholesterol values

     

 Normal to low

 

0/46 (0.0)

 

8/97 (8.2)

.05

Patients with categorical shifts in fasting glucose values

     

 Normal to impaired

 

5/32 (15.6)

 

9/72 (12.5)

.76

 Impaired to high

 

0/18 (0.0)

 

2/28 (7.1)

.51

 Normal/impaired to high

 

0/50 (0.0)

 

3/100 (3.0)

.55

 Normal to high

 

0/32 (0.0)

 

1/72 (1.4)

1.00

  1. Abbreviations: HDL = high-density lipoprotein; LDL = low-density lipoprotein; LS mean = least squares mean; SE = standard error.
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BMC Psychiatry

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