From: Comorbidities in ADHD children treated with methylphenidate: a database study
 | Male | Female | ||||
---|---|---|---|---|---|---|
Diagnostic Group | Incident users | Controls | P-value | Incident users | Controls | P-value |
(N=13,460)%1 | (N=978,790)%1 | (N=3,837)%1 | (N=1,000,300)%1 | |||
Pre-existing cardiovascular disorders | 2.00 | 1.24 | <0.01 | 2.06 | 1.18 | <0.01 |
  Angina pectoris | 0.13 | 0.19 | 0.34 | 0.16 | 0.18 | 0.90 |
  Arterial occlusive disease | 0.01 | 0.02 | 0.98 | 0.08 | 0.03 | 0.04 |
  Potentially life threatening arrhythmias | 0.51 | 0.17 | <0.01 | 0.57 | 0.14 | <0.01 |
  Cardiomyopathy | 0.10 | 0.05 | 0.02 | 0.03 | 0.05 | 0.57 |
  Severe congenital heart disease | 1.23 | 0.78 | <0.01 | 1.20 | 0.75 | <0.01 |
  Heart failure | 0.09 | 0.05 | 0.02 | 0.03 | 0.05 | 0.69 |
  Myocardial infarction | 0.01 | 0.01 | 0.64 | 0.03 | 0.02 | 0.43 |
  Severe hypertension | 0.07 | 0.05 | 0.34 | 0.05 | 0.05 | 0.82 |
Pre-existing cerebrovascular disorders | 0.19 | 0.11 | <0.01 | 0.13 | 0.10 | 0.36 |
Stroke | 0.10 | 0.05 | 0.02 | 0.10 | 0.04 | 0.02 |
Glaucoma | 0.39 | 0.33 | 0.34 | 0.34 | 0.35 | 0.96 |
Hyperthyroidism | 1.22 | 0.15 | <0.01 | 0.89 | 0.27 | <0.01 |