Table 3 Comparison of the genotypic and allelic frequencies of rs1799971 and rs2075572 in different kinds of patients compared with controls by BsmI polymorphisms*
From: Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population
SNP | Gender | Haplotype | Controls | Clinical symptoms | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Delusion of reference | OR(95% CI) | Genuine auditory hallucination | OR(95% CI) | Delusion of persecution | OR(95% CI) | Bizarre behavior) | OR(95% CI) | Apathy | OR(95% CI) | ||||
rs799971 | All | AA | 68 | 53 | 1.00(referent) | 40 | 1.00(referent) | 34 | 1.00(referent) | 51 | 1.00(referent) | 30 | 1.00(referent) |
AG | 133 | 92 | 0.888(0.568-1.387) | 78 | 0.997(0.617-1.612) | 69 | 1.038(0.627-1.718) | 101 | 1.013(0.648-1.581) | 57 | 0.971(0.572-1.65) | ||
GG | 63 | 29 | 0.591(0.335-1.042) | 21 | 0.405(0.204-0.803) | 19 | 0.603(0.312,1.164) | 29 | 0.614(0.347-1.086) | 20 | 0.72(0.371-1.394) | ||
A | 269 | 198 | 1.00(referent) | 158 | 1.00(referent) | 137 | 1.00(referent) | 203 | 1.00(referent) | 117 | 1.00(referent) | ||
G | 259 | 150 | 0.787(0.599-1.033) | 120 | 0.789(0.589-1.057) | 107 | 0.811(0.598-1.101) | 159 | 0.813(0.622-1.064) | 97 | 0.861(0.626-1.184) | ||
Male | AA | 31 | 26 | 1.00(referent) | 24 | 1.00(referent) | 16 | 1.00(referent) | 21 | 1.00(referent) | 15 | 1.00(referent) | |
AG | 85 | 45 | 0.631(0.335-1.19) | 48 | 0.729(0.385-1.383) | 32 | 0.729(0.352-1.51) | 44 | 0.764(0.394-1.483) | 46 | 1.118(0.548-2.282) | ||
GG | 30 | 11 | 0.437(0.184-1.039) | 10 | 0.431(0.176-1.051) | 7 | 0.452(0.163-1.254) | 11 | 0.541(0.223-1.312) | 5 | 0.344(0.111-1.066) | ||
A | 147 | 97 | 1.00(referent) | 96 | 1.00(refrent) | 64 | 1.00(referent) | 86 | 1.00(referent) | 76 | 1.00(referent) | ||
G | 145 | 67 | 0.7(0.476-1.031) | 68 | 0.718(0.488-1.057) | 46 | 0.729(0.468-1.135) | 66 | 0.778(0.524-1.154) | 56 | 0.747(0.494-1.131) | ||
rs2075572 | All | CC | 140 | 91 | 1.00(referent) | 83 | 1.00(referent) | 68 | 1.00(referent) | 90 | 1.00(referent) | 76 | 1.00(referent) |
CG | 100 | 69 | 1.062(0.708-1.591) | 49 | 0.827(0.534-1.279) | 43 | 0.885(0.559-1.402) | 78 | 1.213(0.816-1.805) | 29 | 0.534(0.324-0.88) | ||
GG | 24 | 14 | 0.897(0.441-1.825) | 7 | 0.492(0.203-1.192) | 11 | 0.944(0.437-2.038) | 13 | 0.843(0.408-1.74) | 2 | 0.154(0.035-0.667) | ||
C | 380 | 251 | 1.00(referent) | 215 | 1.00(referent) | 179 | 1.00(referent) | 258 | 1.00(referent) | 181 | 1.00(referent) | ||
G | 148 | 97 | 0.992(0.734-1.342) | 63 | 0.752(0.536-1.056) | 65 | 0.932(0.663-1.312) | 104 | 1.035(0.769-1.392) | 33 | 0.468(0.309-0.71) | ||
Female | CC | 61 | 35 | 1.00(referent) | 45 | 1.00(referent) | 31 | 1.00(referent) | 25 | 1.00(referent) | 64 | 1.00(referent) | |
CG | 49 | 20 | 0.711(0.366-1.384) | 27 | 0.747(0.407-1.371) | 24 | 0.854(0.45-1.621) | 27 | 1.344(0.694-2.605) | 19 | 0.37(0.196-0.698) | ||
GG | 8 | 1 | 0.218(0.026-1.815) | 1 | 0.169(0.02-1.404) | 1 | 0.246(0.029-2.056) | 0 | - | 0 | - | ||
C | 171 | 90 | 1.00(referent) | 117 | 1.00(referent) | 86 | 1.00(referent) | 77 | 1.00(referent) | 147 | 1.00(referent) | ||
G | 65 | 22 | 0.643(0.372-1.111) | 29 | 0.652(0.397-1.072) | 26 | 0.795(0.471-1.342) | 27 | 0.922(0.547-1.557) | 19 | 0.34(0.195-0.593) | ||