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Table 3 Percentage of patients with cognitive impairment * for the total sample of 51 inpatients with therapy-resistant BD depression, BD I, and BD II on nine cognitive tasks from the MCCB, six domain scores and mean composite score, and IQ and change in IQ from the estimated premorbid level

From: Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression

Neurocognitive domain

Total sample

BD I

BD II

BD I vs. BD II

  Test

n = 51

n = 19

n = 32

χ 2

p

Speed of processing

43.1

63.2

31.2

4.9

0.041

  BACS–Symbol Coding

49.0

52.6

46.9

0.2

0.776

  Fluency

17.6

31.6

9.4

4.0

0.062

  TMT-A

45.1

63.2

34.4

4.0

0.080

Attention/Vigilance

36.4a

42.9

33.3

0.4

0.738

  CPT

     

Working memory

21.6

21.1

21.9

0.0

1.000

  Spatial Span

18.0b

26.3

12.9

1.4

0.273

  Letter-Number Span

25.5

31.6

21.9

0.6

0.515

Verbal learning

39.2

42.1

37.5

0.1

0.774

  HVLT-R

     

Visual learning

24.5c

38.9

16.1

3.2

0.094

  BVMT-R

     

Reasoning

30.0b

22.2

34.4

0.8

0.523

  Mazes

     

Mean composite score

31.4

42.1

25.0

1.6

0.228

IQ

5.9

15.8

0.0

5.4

0.047

  WASI

     

IQ decline (NART-WASI) ≥1.5 SD

15.2d

33.3

3.6

7.5

0.010

  1. *Defined as at least 1.5 SD below the normal mean.
  2. a n = 44, b n = 50, c n = 49, d n = 46 due to missing data.