Table 1 Characteristics and clinical features of 10 NMDAR antibody positive patients and negative controls

1(A) encephalitis group

18/F

anti-NMDAR encephalitis

talkativeness, hyperactivity, bizzare behavoir

generalized tonic-clonic seizure

normal

steroid pulse therapy

slight high density inside the bilateral temporal regions (FLAIR, T2)

Dr Dalmau (University of Pennsylvania)

[14]

2(A) encephalitis group

24/M

anti-NMDAR encephalitis

delusion, catalepsy, palilalia

generalized tonic-clonic seizure

11Hz, alpha wave, (after stroid pulse therapy)

steroid pulse therapy

Dr Dalmau (University of Pennsylvania)

[15]

3(A) encephalitis group

27/F

anti-NMDAR encephalitis

substupor, catatonia

unspecified seizure

normal

antipyschotics, m-ECT

after m-ECT, ataxia, nystagmus and agraphia were pointed out

Dr Tanaka(Kanazawa Medical University)

N(A) type antibody-negative (n=2)

59/F, 25/M

Limbic encephalitis suspected

stupor, catatonia, hyperactivity, bizzare behavoir,reference delusion

generalized tonic-clonic seizure (n=1)

spike and wave complex (n=1), diffuse slow alpha wave (n=2)

antipyschotics, m-ECT (n=1)

prodromal ful-like symptoms (n=1)

4(B) narcolepsy with psychosis group

61/M

Narcolepsy, Parkinson's disease, Delusional disorder(297.1)(F22.0)

visual hallucination, persecutory delusion, delusion of jealousy

(-)

short sleep latency, sleep onset REM periods

antipyschotics, m-ECT

resting tremor, hypocretin deficient narcolepsy

Dr Tanaka(Kanazawa Medical University)

[16, 17]

5(B) narcolepsy with psychosis group

37/F

Narcolepsy, Schizophrenia(Paranoid type 295.30)(F20.0)

visual and auditory hallucinations, delusion

(-)

short sleep latency, sleep onset REM periods

antipyschotics

hypocretin deficient narcolepsy

Dr Tanaka(Kanazawa Medical University)

6(B) narcolepsy with psychosis group

24/F

Narcolepsy, Schizophrenia(Paranoid type 295.30)(F20.0)

auditory hallucination, delusion, agitation, aggression,

(-)

short sleep latency, sleep onset REM periods

antipyschotics

hypocretin deficient narcolepsy

Dr Tanaka(Kanazawa Medical University)

N(B) type antibody-negative (n=2)

25/F, 35/M

Narcolepsy and psychosis (25/F)(298.9)(F29), Narcolepsy and Schizophrenia (35/M)(F20.1)(295.10)

agitation, aggression, auditory hallucination

(-)

short sleep latency, sleep onset REM periods

antipyschotics

hypocretin deficient narcolepsy

7(C) psychiatric sympotoms

53/F

Schizophrenia(Catatonic type:295.20)(F20.24), Mental Reterdation(F71.0)

premenstrual tension, atypical pyschosis

generalized tonic-clonic seizure

normal

antipyschotics, m-ECT

Dr Tanaka(Kanazawa Medical University)

8(C) psychiatric sympotoms

34/F

Schizoaffective disorder(295.70)(bipolar type:F25.0)

delusion, auditory hallucination, talkativeness, hyper activity, aggression

complex partial seizure

normal

valproic acid

reccurent ovarian cyst, operations were performed

Dr Tanaka(Kanazawa Medical University)

9(C) psychiatric sympotoms

30/F

Schizophrenia(Disorganized type:295.10)(F20.12)

acoustic hyperesthesia, irritation

(-)

normal

antipyschotics, m-ECT

oral dyskinesia

Dr Tanaka(Kanazawa Medical University)

[18]

10(C) psychiatric sympotoms

26/F

Schizophrenia(Catatonic type:295.20)(F20.25)

hallucination, delusion, depressive mood, hyper activity

(-)

normal

antipyschotics, m-ECT

ovarian tumor, operation was performed

Dr Dalmau (University of Pennsylvania)

[19]

N(C) type antibody-negative (n=47)

15-72y, M:F=10:37

Schizophrenia(295.30,295.20)(F20.0.F20.2), Schizoaffective disorder(295.70), brief psychotic disorder(298.8)(F23.1)

hallucination, delusion, depressive mood, hyper activity, bizzare behavoir, catatonia

generalized tonic-clonic seizure (n=10)

abnormal EEG (n=6)

antipyschotics, m-ECT

ovarian tumor (n=6), convulsion&ovarian tumor (n=2)