Table 3 Plasma pharmacokinetic parameters of paliperidone following injections of paliperidone palmitate (150 mg eq.) (pharmacokinetic analysis set)
| Â | Â | Â | Geometric | Ratio | Confidence Interval |
|---|---|---|---|---|---|
PK parameter | Injection | N | LSM | (Test/Reference)a | (90%) |
AUCÏ„, ng.h/mL | 2nd injection | 96 | 21924.25 | Â | Â |
| Â | 8th injection | 96 | 26638.65 | 121.50 | (114.42;129.03) |
| Â | 14th injection | 96 | 31522.41 | 143.78 | (135.39;152.68) |
Cmax, ng/mL | 2nd injection | 99 | 46.74 | Â | Â |
| Â | 8th injection | 99 | 49.42 | 105.75 | (98.82;113.16) |
| Â | 14th injection | 99 | 57.74 | 123.55 | (115.46;132.21) |
Note: Data analyzed on log-scale but transformed back to the original scale | |||||
LSM = Least-Squares Means | |||||