Table 2 Median pharmacokinetic parameters after intramuscular injections of paliperidone palmitate (150 mg eq.)
| Â | 2nd injection | 8th injection | 14th injection | |||
|---|---|---|---|---|---|---|
PK parameter | N | Median (min-max) | N | Median (min-max) | N | Median (min-max) |
Cpredose, ng/mL | 200 | 21.3 (0.46-81.2) | 119 | 28.4 (6.03-92.6) | 105 | 39.9 (9.17-134) |
Cmin, ng/mL | 189 | 17.0 (0.46-46.7) | 114 | 27.0 (6.03-92.6) | 105 | 35.1 (9.17-120) |
Cmax, ng/mL | 189 | 50.5 (11.5-232) | 114 | 50.5 (10.7-172) | 105 | 56.5 (17.6-172) |
tmax, daysa | 189 | 7.96 (0.00-28.02) | 114 | 8.48 (0.00-30.95) | 105 | 7.00 (0.00-30.00) |
AUCtau, h*ng/mL | 183 | 23325 (3652-86457) | 111 | 26831 (6335-87393) | 105 | 31970 (9244-96840) |
Cavg, ng/mL | 183 | 34.7 (5.44-129) | 114 | 40.0 (9.42-130) | 105 | 47.8 (13.8-144) |
FI, % | 183 | 92.7 (39.8-215) | 114 | 55.0 (15.6-179) | 105 | 41.2 (5.83-111) |