Skip to main content

Table 1 Baseline predictors associated with categorical improvement after 6 Months and 12 Months of treatment with OLAI

From: Schizophrenia symptoms and functioning in patients receiving long-term treatment with olanzapine long-acting injection formulation: a pooled analysis

 

Logistic regression statistics

Model

Odds ratio

95% CI of Odds ratio

p-value (for effect)

Single variable model 6 Months

 Age [1 year]

0.989

0.975; 1.002

0.0937

 Time since diagnosis [1 year]

0.979

0.959; 0.998

0.0327

 Working status

   

  unemployed vs. retired

1.023

0.620; 1.688

0.9287

  working vs. retired

1.564

0.925; 2.644

0.0948

 Clinical Study

   

  HGKA vs. HGKB

1.890

1.262; 2.830

0.0020

  HGLQ vs. HGKB

0.972

0.603; 1.566

0.9068

 Baseline category

   

  C vs. B

3.007

1.966; 4.600

<0.0001

  D vs. B

6.656

4.386; 10.099

<0.0001

  E vs. B

3.043

1.585; 5.841

0.0008

 CGI-S [1 point higher at baseline]

0.787

0.659; 0.941

0.0084

 PANSS total [1 point higher at baseline]

1.010

1.000; 1.020

0.0622

  PANSS positive

1.553

1.210; 1.992

0.0005

  PANSS anxiety/depression

1.326

1.066; 1.649

0.0111

  PANSS hostility

1.253

0.992; 1.583

0.0586

 QLS total [1 point higher at baseline]

1.135

1.035; 1.245

0.0072

  QLS Instrumental role funct.

1.151

1.026; 1.291

0.0162

  QLS Interpersonal relations

1.159

1.008; 1.333

0.0381

 Remission baseline [yes vs, no]

1.061

0.778; 1.449

0.7078

 Remission 6 months [yes vs. no]

2.420

1.670; 3.507

<0.0001

Stepwise multivariate logistic regression 6 Months

   

 PANSS positive

2.840

1.834; 4.399

<0.0001

 CGI-S

0.619

0.463; 0.828

0.0012

Single variable model 12 Months

 Clinical Study

   

  HGKA vs. HGKB

1.592

1.048; 2.418

0.0294

  HGLQ vs. HGKB

0.905

0.562; 1.458

0.6811

 Baseline category

   

  C vs. B

3.316

2.085; 5.271

<0.0001

  D vs. B

6.936

4.351; 11.057

<0.0001

  E vs. B

5.879

2.742; 12.605

<0.0001

 PANSS total

1.018

1.006; 1.029

0.0024

  PANSS positive

1.798

1.354; 2.387

<0.0001

  PANSS anxiety/depression

1.370

1.066; 1.761

0.0141

  PANSS disorganized

1.390

1.062; 1.821

0.0167

  PANSS hostility

1.565

1.193; 2.053

0.0012

 QLS total

1.157

1.045; 1.281

0.0049

  QLS Instrumental role funct.

1.178

1.038; 1.337

0.0112

  QLS Interpersonal relations

1.167

0.999; 1.363

0.0520

 Remission baseline

1.013

0.720; 1.426

0.9391

 Remission 12 months

2.628

1.710; 4.039

<0.0001

Stepwise multivariate logistic regression 12 Months

   

 PANSS positive

1.537

1.129; 2.093

0.0063

  1. In total, 22 variables were assessed in the single variable logistic regression models. Variables in bold were identified as potentially overlapping variables and were not included in the stepwise multivariate logistic regression model. CGI-S: Clinical Global Impression – Severity, CI: confidence interval, PANSS: Positive and Negative Symptoms Score, QLS: Heinrich Carpenter’s Quality of Life Scale.