Mu opioid receptor availability in people with psychiatric disorders who died by suicide: a case control study

BMC Psychiatry

Table 2 Levels of [3 H]DAMGO (mean ± SEM) binding in subjects with schizophrenia, major depressive disorder, bipolar disorder or no history of psychiatric disorder who did or did not die as a result of suicide

Group BA 24	Sample size	[3 H]DAMGO binding (fmole/mg ETE)	Analysis parameters	P value
Suicide	41	32.25 ± 1.76	t = 2.7, df = 120 (non-suicide)	0.008
Non-suicide	81	38.34 ± 1.34
Diagnosis/suicide	BA 24
Controls	51	37.63 ± 1.83
Suicides	9	34.02 ± 3.80	t = 0.88 (controls)	n.s
MDD	5	27.95 ± 9.06	t = 1.84 (controls)	n.s
MDD (suicide)	15	35.69 ± 2.84	t = 0.58 (controls)	n.s
BP	8	50.51 ± 1.98	t = 3.00 (controls)	n.s
BP (suicide)	5	35.38 ± 3.07	t = 0.43 (controls)	n.s
Schizophrenia	26	37.80 ± 1.83	t = 0.04 (controls)	n.s
Schizophrenia (suicide)	12	25.31 ± 3.17	t = 3.39 (controls) t = 3.21 (schizophrenia)	<0.05
Schizophrenia/suicide	BA 9
Controls	20	31.65 ± 2.11
Schizophrenia	26	34.40 ± 1.32	t = 1.15 (controls)	n.s
Schizophrenia (suicide)	12	24.12 ± 2.27	t = 2.57 (controls) t = 3.68 (schizophrenia)	<0.05 <0.05
	CPu
Controls	20	25.40 ± 2.16
Schizophrenia	24	23.72 ± 1.37	t = 0.67 (controls)	n.s
Schizophrenia (suicide)	11	16.29 ± 2.42	t = 2.97 (controls) t = 2.50 (schizophrenia)	<0.05 <0.05

The group comparison the analysis factors refer to is given in brackets below the parameters. Abbreviations: n.s. = not significant.

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