Long-acting antipsychotic drugs for the treatment of schizophrenia: use in daily practice from naturalistic observations

Table 2 Percentages of the most frequent and selected general adverse events reported for different long-acting antipsychotic drugs

Drug	FL	R	R	R	R, in no r	R in r	R	R vs oral	R	R	R y	R a	R	R	R	R	V	Z
Reference	[131]	[15]	[79]	[86]	[84]	[84]	[85]	[88]	[89]	[90]	[91]	[91]	[105]	[107]	[132]	[133]	[88]	[76]
n	16	715	192	202	312	82	1476	100	40	249	66	351	336	725	87	529	565	19
Anxiety	12.5	12	12	15	28.7	24.5	6.9	11.0	---	11	21	23	22.3	26	16.1	23.9	---	---
Insomnia	6.2	10	9	9	26.5	25.0	7.0	9.0	5.0	6	29	19	23.5	22	16.1	18.7	---	8
Disease exacerbation	---	---	10	---	20.1	15.8	6.1	5.0	---	6	12	12	18.2	15	19.5	7.4	---	---
Depressive reactions	17	---	6	---	19.8	15.7	---	5.0	---	---	17	14	19.3	15	---	11.3	---	25
Headache	---	---	---	---	14.7	14.7	---	---	2.5	6	21	11		---	11.5	7.7	---	---
GI symptoms^a	---	---	---	---	---	---	---	---	---	---	11	3	---	---	---	---	---	17
Glucose-related AEs	---	---	---	0.5^b	---	---	---	---	---	---	---	---	---	---	0.0	0.8^c	0.0	---
Prolactin-related AEs^d	---	---	---	0.5	---	---	---	6.0	2.5^f	2.8	---	---	---	---	---	---	0.4^e	---
Sedation/Somnolence	---	---	---	---	---	---	---	---	---	---	12	5	---	---	---	---	---	---
Rhinitis	---	---	---	---	---	---	---	---	---	---	18	11	---	---	---	---	---	---
Fatigue	---	---	---	---	---	---	---	---	---	---	15	7	---	---	---	---	---	---
Others	6.2^h	---	---	---	---	---	---	---	2.5^g,h	---	---	---	---	---	---	---	---	17^h

Abbreviations: FL = flupenthixol; R = risperidone; r = remission; y = in young patients; a = in adult patients; V = various; Z = zuclopenthixol decanoate; GI = gastrointestinal; AEs = adverse events; --- = not reported.
^aIncludes dyspepsia, nausea, and vomiting.
^bNew onset type 2 diabetes mellitus (n = 1).
^cNew onset type 2 diabetes mellitus (n = 3) and hyperglycemia (n = 1).
^dIncludes loss of libido, sexual impotence, galactorrhea, and gynecomastia.
^eImpotence (n = 1) and galactorrhea (n = 1).
^fIrregular menstruation (n = 1).
^gDisturbances in accommodation.
^hDizziness.

ISSN: 1471-244X