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Table 1 Studies included in the Meta-analyses

From: Structural brain changes in first episode Schizophrenia compared with Fronto-Temporal Lobar Degeneration: a meta-analysis

First author, Year of publication

Disorder type

Number of patients

Number of controls

Mean age of patients (yrs)

Mean age of controls (yrs)

FIRST EPISODE SCHIZOPHRENIA

   

  Berge, 2010 [32]

PNOS (FE)

21

20

24.8

25.3

  Chua, 2007 [33]

SZ, SZF, BPSY (FE)

26

38

32.0

33.0

  Douaud, 2007 [34]

SZ (FE)

25

25

16.5

16.2

  Ebdrup, 2010 [35]

SZ (FE)

38

43

26.2

26.9

  Jayakumar, 2005 [36]

SZ (FE)

18

18

24.9

25.7

  Job, 2002 [37]

SZ (FE)

34

36

21.4

21.2

  Kasparak, 2007 [38]

SZ (FE)

22

18

23.7

24.1

  Kubicki, 2002 [39]

SZ (FE)

16

18

26.0

24.0

  Lui, 2009 [40]

SZ (FE)

68

68

24.2

24.7

  Meda, 2008 [41]

WPIC

22

21

25.1

26.2

  Molina, 2010 [42]

SZ (FE)

30

41

25.8

29.4

  Price, 2010 [43]

SCZ, SZA (FE)

48

47

26.2

24.8

  Salgado-Pineda, 2003 [44]

SZ (FE)

13

13

23.8

23.4

  Schaufelberger, 2007 [45]

SZ, SZF (FE)

62

94

27.6

30.2

  Venkatasubramanian, 2010 [46]

SZ (FE)

30

27

30.1

27.4

  Whitford, 2005 [47]

SZ (FES)

41

47

19.8

19.3

  Witthaus, 2009 [48]

SZ (FES)

23

29

26.4

25.7

  Yoshihara, 2008 [49]

SZ (FES)

18

18

15.8

15.8

Total (mean)

 

555 (30.8)

621 (34.5)

(24.4)

(24.5)

FRONTO-TEMPORAL LOBAR DEGENERATION

    

  Adlam, 2006 [50]

FTLD: SD, fPPA

6

12

62.8

65.0

  Boccardi, 2005 [51]

FTLD

9

26

62.0

69.0

  Boxer, 2003 [52]

FTLD: SD

11

15

66.2

69.6

  Chang, 2005 [53]

FTLD: FTLD&ALS vs. ALS

10

10

64.5

49.9

  Desgranges, 2007 [54]

FTLD: SD

10

17

65.7

65.8

  Gee, 2003 [55]

FTLD

29

12

65.1

68.5

  Gorno-Tempini, 2004 [56]

FTLD: SD

10

10

63.0

69.1

  Grossman, 2004 [57]

FTLD

29

12

65.1

68.5

  Kanda, 2008 [58]

FTLD: bvFTD

13

20

64.9

65.2

  Kim, 2007 [59]

FTLD

14

61

63.3

68.0

  Libon 2009 [60]

FTLD: bvFTD

51

43

61.3

n/av: age-matched

  Massimo 2009 [61]

FTLD: disinhibition-predominant

4

10

63.6

64.1

  Mummery 2000 [62]

FTLD: SD

6

14

60.5

62.0

  Nestor 2003 [63]

FTLD: PNFA

7

10

71.5

65.9

  Pardini 2009 [64]

FTLD: bvFTD

22

12

60.3

n/av: age-matched

  Pereira 2009 [65]

FTLD: ubiquitin positive

9

25

64.0

63.8

  Rabinovici 2007 [66]

FTLD

18

40

62.5

63.5

  Rosen 2002 [67]

FTLD: bvFTD

20

20

61.8

62.3

  Seeley 2008 [68]

FTLD: bvFTD CDR2-3

15

45

62.3

68.3

  Williams 2005 [69]

FTLD

18

17

60.8

61.7

Total (mean)

 

311 (15.6)

431 (21.6)

(63.6)

(65.0)

  1. All studies using voxel-based morphometry of gray matter compared a patient group with a comparison group. Abbreviations: BPSY, Brief Psychotic Disorder; FE, First episode; PNOS, Psychosis not otherwise specified; SZ, Schizophrenia; SZA, Schizo-affective disorder; SZF, Schizophreniform disorder; WPIC, Patients from the Western Psychiatric Institute and Clinic at the University of Pittsburgh; FTLD, Fronto-temporal Lobar Degeneration; SD, Semantic Dementia; fPPA, Fluent form of Primary Progressive Aphasia; ALS, Amyotrophic Lateral Sclerosis; bvFTD, behavioural / dysexecutive subtype of FTLD; PFNA, Progressive non-fluent Aphasia; CDR, Clinical Dementia Rating (range: 0.5 – 3); n/av, data not available.