Skip to main content

Table 1 HA scores (Mean ± Standard Deviation) of all participants, including screened healthy subjects and people excluded for depression and anxiety disorders, stratified according to the 5-HTTLPR and the 5-HTTLPR/rs25531 estimated/phased haplotypes

From: The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits

  All subjects (287) Healthy subjects (229) Disordered subjects b(55)
Genotype 5-HTTLPR N (freq. %) HA (mean ± SD) p (ANCOVA) a N (freq. %) HA (mean ± SD) p (ANCOVA) a N (freq. %) HA (mean ± SD) p (ANCOVA) a
LL 107 (0.37) 43.42 ± 17.14 F = 2.84 93 (0.41) 41.63 ± 15.66 F = 0.34 13 (0.24) 57.14 ± 21.73 F = 1.85
LS 138 (0.48) 42.55 ± 17.96 p = 0.06 109 (0.48) 39.08 ± 16.72 p = 0.71 27 (0.49) 56.19 ± 16.88 p = 0.17
SS 42 (0.15) 48.57 ± 20.18   27 (0.11) 37.25 ± 12.11   15 (0.27) 68.95 ± 15.11  
Carriers          
Carriers L 245 (0.85) 42.93 ± 17.57 F = 5.73 202 (0.89) 40.25 ± 16.25 F = 0.18 40 (0.73) 56.50 ± 18.32 F = 3.86
vs SS    p = 0.02    p = 0.67    p = 0.05
Carriers S 180 (0.63) 43.95 ± 18.62 F = 0.37 136 (0.59) 38.72 ± 15.89 F = 0.70 42 (0.76) 60.75 ± 17.24 F = 0.60
vs LL    p = 0.54    p = 0.40    p = 0.44
Phased Haplotype frequencies
LALA 93 (0.32) 42.27 ± 16.60 F = 2.00 82 (0.36) 40.70 ± 14.97 F = 0.59 10 (0.18) 56.29 ± 23.41 F = 1.14
LALG 14 (0.05) 51.02 ± 19.28 p = 0.09 11 (0.05) 48.57 ± 19.55 p = 0.67 3 (0.05) 60.00 ± 18.73 p = 0.35
LASA 120 (0.42) 42.41 ± 17.58   94 (0.41) 38.85 ± 16.14   25 (0.46) 55.20 ± 17.16  
LGSA 18 (0.06) 43.49 ± 20.82   15 (0.07) 40.57 ± 20.58   2 (0.04) 68.57 ± 4.04  
SASA 42 (0.15) 48.57 ± 20.18   27 (0.11) 37.25 ± 12.11   15 (0.27) 68.95 ± 15.11  
Clustered Phased Haplotype frequencies
L'L' 93 (0.32) 42.27 ± 16.60 F = 2.12 82 (0.36) 40.70 ± 14.97 F = 0.04 10 (0.18) 56.29 ± 23.41 F = 2.50
L'S' 134 (0.47) 43.30 ± 17.88 p = 0.12 105 (0.46) 39.86 ± 16.69 p = 0.96 28 (0.51) 55.71 ± 17.03 p = 0.09
S'S' 60 (0.21) 47.05 ± 20.34   42 (0.18) 38.43 ± 15.50   17 (0.31) 68.91 ± 14.17  
Carriers of Phased haplotypes
(L'L' + L'S') 227 (0.79) 47.05 ± 20.34 F = 3.92 187 (0.82) 38.43 ± 15.50 F = 0.08 38 (0.69) 68.91 ± 14.17 F = 5.15
vs (S'S')    p = 0.05    p = 0.77    p = 0.03
(L'S' + S'S') 194 (0.68) 44.46 ± 18.70 F = 1.47 147 (0.64) 39.45 ± 16.32 F = 0.04 45 (0.82) 60.70 ± 17.11 F = 0.81
vs L'L'    p = 0.23    p = 0.85    p = 0.37
  1. The ANCOVA results for the genotypes, clustered genotype, and carriers are included.
  2. a HA score as the dependent variable, genotype or clustered genotype and sex as independent variables, and age as a covariate.
  3. b Disordered group consisted of subjects with depression and anxiety disorders.