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Table 1 HA scores (Mean ± Standard Deviation) of all participants, including screened healthy subjects and people excluded for depression and anxiety disorders, stratified according to the 5-HTTLPR and the 5-HTTLPR/rs25531 estimated/phased haplotypes

From: The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits

 

All subjects (287)

Healthy subjects (229)

Disordered subjects b(55)

Genotype 5-HTTLPR

N (freq. %)

HA (mean ± SD)

p (ANCOVA) a

N (freq. %)

HA (mean ± SD)

p (ANCOVA) a

N (freq. %)

HA (mean ± SD)

p (ANCOVA) a

LL

107 (0.37)

43.42 ± 17.14

F = 2.84

93 (0.41)

41.63 ± 15.66

F = 0.34

13 (0.24)

57.14 ± 21.73

F = 1.85

LS

138 (0.48)

42.55 ± 17.96

p = 0.06

109 (0.48)

39.08 ± 16.72

p = 0.71

27 (0.49)

56.19 ± 16.88

p = 0.17

SS

42 (0.15)

48.57 ± 20.18

 

27 (0.11)

37.25 ± 12.11

 

15 (0.27)

68.95 ± 15.11

 

Carriers

         

Carriers L

245 (0.85)

42.93 ± 17.57

F = 5.73

202 (0.89)

40.25 ± 16.25

F = 0.18

40 (0.73)

56.50 ± 18.32

F = 3.86

vs SS

  

p = 0.02

  

p = 0.67

  

p = 0.05

Carriers S

180 (0.63)

43.95 ± 18.62

F = 0.37

136 (0.59)

38.72 ± 15.89

F = 0.70

42 (0.76)

60.75 ± 17.24

F = 0.60

vs LL

  

p = 0.54

  

p = 0.40

  

p = 0.44

Phased Haplotype frequencies

LALA

93 (0.32)

42.27 ± 16.60

F = 2.00

82 (0.36)

40.70 ± 14.97

F = 0.59

10 (0.18)

56.29 ± 23.41

F = 1.14

LALG

14 (0.05)

51.02 ± 19.28

p = 0.09

11 (0.05)

48.57 ± 19.55

p = 0.67

3 (0.05)

60.00 ± 18.73

p = 0.35

LASA

120 (0.42)

42.41 ± 17.58

 

94 (0.41)

38.85 ± 16.14

 

25 (0.46)

55.20 ± 17.16

 

LGSA

18 (0.06)

43.49 ± 20.82

 

15 (0.07)

40.57 ± 20.58

 

2 (0.04)

68.57 ± 4.04

 

SASA

42 (0.15)

48.57 ± 20.18

 

27 (0.11)

37.25 ± 12.11

 

15 (0.27)

68.95 ± 15.11

 

Clustered Phased Haplotype frequencies

L'L'

93 (0.32)

42.27 ± 16.60

F = 2.12

82 (0.36)

40.70 ± 14.97

F = 0.04

10 (0.18)

56.29 ± 23.41

F = 2.50

L'S'

134 (0.47)

43.30 ± 17.88

p = 0.12

105 (0.46)

39.86 ± 16.69

p = 0.96

28 (0.51)

55.71 ± 17.03

p = 0.09

S'S'

60 (0.21)

47.05 ± 20.34

 

42 (0.18)

38.43 ± 15.50

 

17 (0.31)

68.91 ± 14.17

 

Carriers of Phased haplotypes

(L'L' + L'S')

227 (0.79)

47.05 ± 20.34

F = 3.92

187 (0.82)

38.43 ± 15.50

F = 0.08

38 (0.69)

68.91 ± 14.17

F = 5.15

vs (S'S')

  

p = 0.05

  

p = 0.77

  

p = 0.03

(L'S' + S'S')

194 (0.68)

44.46 ± 18.70

F = 1.47

147 (0.64)

39.45 ± 16.32

F = 0.04

45 (0.82)

60.70 ± 17.11

F = 0.81

vs L'L'

  

p = 0.23

  

p = 0.85

  

p = 0.37

  1. The ANCOVA results for the genotypes, clustered genotype, and carriers are included.
  2. a HA score as the dependent variable, genotype or clustered genotype and sex as independent variables, and age as a covariate.
  3. b Disordered group consisted of subjects with depression and anxiety disorders.
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BMC Psychiatry

ISSN: 1471-244X

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