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Table 1 Baseline characteristics for schizophrenic patients with monotherapy and polypharmacy (n = 183).

From: Relapse according to antipsychotic treatment in schizophrenic patients: a propensity-adjusted analysis

 

Patients with monotherapy

(n = 114)

Patients with polypharmacy

(n = 69)

P value

 

M

(SD)1

M

(SD)

 

Socio-demographic characteristics

     

Gender (male), N (%)2

79

(69.3)

50

(73.5)

0.54

Age

37.9

(10.5)

40.6

(10.3)

0.08

Living conditions (Alone), N (%)

35

(30.7)

30

(43.5)

0.08

Clinical characteristics

     

Age at onset of illness

25.43

(8.20)

22.65

(7.28)

0.03

Total PANSS3 score

65.3

(18.0)

70.0

(22.2)

0.14

   Positive PANSS score

14.0

(5.3)

13.7

(5.6)

0.74

   Negative PANSS score

18.0

(6.9)

19.6

(8.2)

0.16

   General Psychopathology PANSS score

33.3

(9.8)

36.7

(11.6)

0.04

GAF4 score

54.0

(14.0)

51.0

(16.3)

0.20

GARF5 score

55.7

(16.7)

54.3

(17.7)

0.59

SOFAS6 score

53.9

(13.4)

50.7

(15.7)

0.15

CDSS7 score

2.7

(3.3)

3.8

(4.1)

0.07

Medication

     

Drugs for side-effects§, N (%)

40

(35.0)

42

(60.9)

<0.01

Sedative drugs§§, N (%)

49

(43.0)

46

(66.7)

<0.01

Antidepressant, N (%)

18

(15.8)

20

(29.0)

0.03

AIMS8

2.7

(4.3)

3.1

(4.6)

0.53

BAS9

1.0

(1.9)

1.1

(2.1)

0.71

SAS10

2.9

(3.3)

3.8

(4.0)

0.13

ROMI11

     

Compliance score

12.2

(2.8)

13.0

(2.7)

0.09

Non compliance score

14.2

(3.7)

14.0

(3.8)

0.74

Number of previous hospitalisations

5.5

(5.3)

7.5

(6.9)

0.05

Quality of life: SF-36

     

Physical Functioning

82.0

(20.5)

76.3

(22.9)

0.10

Role-Physical Limitations

74.2

(32.9)

65.9

(40.2)

0.15

Bodily Pain

72.7

(26.3)

71.9

(27.6)

0.85

General Health

58.2

(21.4)

58.3

(21.0)

0.98

Vitality

50.9

(19.1)

48.0

(17.9)

0.34

Mental Health

63.4

(20.4)

59.5

(17.3)

0.21

Role-Emotional Limitations

74.3

(36.4)

60.8

(40.2)

0.03

Social Functioning

68.9

(30.1)

67.1

(25.8)

0.70

Relapse, N (%)

27

(23.7)

23

(33.3)

0.16

  1. 1 Mean (Standard Deviation)
  2. 2 Effective (Percentage)
  3. 3 Positive and Negative Syndrome Scale; 4Global Assessment Functioning; 5Global Assessment of Relational Functioning; 6Social and Occupational Functioning Assessment Scale; 7Calgary Depression Scale for Schizophrenia; 8Abnormal Involuntary Movement Score; 9Barnes Akathisia score; 10Simpson-Angus score; 11Rating of Medication Influences Scale.
  4. § Drugs for side effects: Biperiden hydrochloride, Tropatepine hydrochloride, and Trihexyphenidyl hydrochloride.
  5. §§ Sedative drugs: Benzodiazepines, Antihistamines, and Hypnotics.
  6. Values significant at the 5% level are marked in bold.