From: Paliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis
Paliperidone ER | ||||||
---|---|---|---|---|---|---|
Study (Year Completed) | N* | Population | Dose (mg/day) | Duration (Weeks) | Efficacy Measures | Safety Measures |
PALI-SCH-303 (2005) [7] | 500† | • Patients with schizophrenia, diagnosis for ≥1 yr • Agreed to hospitalization for at least the first 14 days of the study • Acute episode with PANSS total score 70-120 | 6, 9, 12 (qd) | 6 | PANSS, CGI | SAS, BARS, AIMS, AEs, labs, weight |
PALI-SCH-304 (2004) [8] | 327† | • Patients with schizophrenia, diagnosis for ≥1 yr • Agreed to hospitalization for at least the first 14 days of the study • Acute episode with PANSS total score 70-120 | 6, 12 (qd) | 6 | PANSS, CGI | SAS, BARS, AIMS, AEs, labs, weight |
PALI-SCH-305 (2005) [9] | 366† | • Patients with schizophrenia, diagnosis for ≥1 yr • Agreed to hospitalization for at least the first 14 days of the study • Acute episode with PANSS total score 70-120 | 3, 9, 15 (qd) | 6 | PANSS, CGI | SAS, BARS, AIMS, AEs, labs, weight |
Risperidone | ||||||
Study | N | Population | Dose (mg/day) | Duration (Weeks) | Efficacy Measures | Safety Measures |
RIS-USA-1 (1990)‡ | 160 | • Patients with schizophrenia • Inpatients at the start of the study • Minimum BPRS score of 30, with a minimum score of at least moderate (4) on 2 of the following items: conceptual disorganization, suspiciousness, hallucinatory behavior, unusual thought content | 1-10§ (qd) | 6 | BPRS, CGI | ESRS, AIMS, AEs, labs, weight |
523 | • Patients with chronic schizophrenia • Inpatients at the start of the study • PANSS total score 60-120 | 2, 6, 10,16 (bid) | 8 | PANSS, CGI | ESRS, AEs, labs, weight | |
RIS-USA-72 (1996)‡ | 246 | • Patients with schizophrenia • Inpatients at the start of the study • PANSS total score 80-120, with a PANSS score ≥8 for the sum of 2 of the following items: conceptual disorganization, suspiciousness, hallucinatory behavior, unusual thought content | 4, 8 (qd) | 4 | PANSS | ESRS, AEs, labs, weight |