Table 2 Study characteristics
Study | Number of participants | Blinding | Design | Follow-up | Baseline severity ADHD-RS total score | Mean daily dose-atomoxetine and frequency | Mean daily dose-methylphenidate and frequency |
|---|---|---|---|---|---|---|---|
Yildiz 2010 | n = 25 | Open label | Parallel group | 12 weeks | Parents T-DSM-IV inattention scores atomoxetine = 16.72 MPH = 17.72 | 1.28 mg/kg/day Once a day | OROS-MPH = 1.07 mg/kg (IR = equivalent 0.89 mg/kg) Once a day |
Newcorn 2008 | n = 442 | Double blind | Parallel group | 6 weeks | Atomoxetine = 40.9(SD 8.8) MPH = 40.0 (SD 8.8) | 1.45 mg/kg Twice a day | OROS-MPH = 1.16 mg/kg (IR equivalent = 0.966 mg/kg Once a day |
Prasad 2007 | n = 180 | Open label | Parallel group | 10 weeks | Atomoxetine = 45.5(SD 8.7) MPH not stated | 1.5 mg/kg Once a daily 8 pts got twice daily | IR MPH = 0.8 mg/kg OROS-MPH = 1.03 mg/kg (IR equivalent = 0.858 mg/kg) |
Wang 2007 | n = 330 | Double blind | Parallel group | 8 weeks | Atomoxetine = 38.6 (SD 7.6) MPH = 37.4 (SD 7.6) | Final range 0.8 mg/kg-1.8 mg/kg Once a day | IR MPH = 17.8/mg/day Twice a day |
Kemner 2005 | n = 1323 | Open label | Parallel group | 3 weeks | Atomoxetine = 38.6 (SD8.1) MPH = 39. | 1.08 mg/kg/Once a day | OROS-MPH 1.01 mg/kg/day (IR equivalent 0.841 mg/kg) Once a day |
Sangal 2005 | n = 85 | Double blind | Cross over | 7 weeks | Atomoxetine = 39.6 MPH not stated | 1.56 mg/kg/day Twice a day | IR MPH = 1.12 mg/kg Three times a day |
Kratochvil 2002 | n = 228 | Open label | Parallel group | 10 weeks | Atomoxetine = 39.4 MPH = 37.6 | 0.48 mg/kg* or 1.4 mg/kg/kg** Twice daily | Final mean dose 0.85 mg/kg Three times a day |
Spencer 2002 HFBD | n = 84 | Double blind | Parallel group | 9 weeks | Atomoxetine = 39.5 | 1.56 mg/kg Twice a day | IR MPH = 1.12 mg/kg Twice a day |
Spencer 2002 HFBK | n = 79 | Double blind | Parallel group | 9 weeks | Atomoxetine = 39.5 | 1.56 mg/kg Twice a day | IR MPH = 1.12 mg/kg Twice a day |