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Table 1 Baseline Characteristics for Responder Groupsa among patients with chronic schizophrenia treated with olanzapine LAI

From: Early response predicts subsequent response to olanzapine long-acting injection in a randomized, double-blind clinical trial of treatment for schizophrenia

Baseline Characteristics

Early

Responders

(n = 137)

Early

Non-responders

(n = 96)

p-value

Age, years (mean [SD])

40.8 (11.6)

38.8 (11.1)

.18

Female gender, (n [%])

35 (25.6)

30 (31.3)

.34

Race (n [%])

  

.75

   White

81 (59.1)

55 (57.3)

 

   African American

47 (34.3)

33 (34.4)

 

   Hispanic

8 (5.8)

5 (5.2)

 

   Other

1 (0.7)

3 (3.1)

 

Age at first schizophrenia episode, years

(mean [SD])

23.7 (7.9)

22.1 (8.7)

.15

PANSS scores (mean[SD])

   

   Total

102.5 (16.0)

97.5 (12.3)

.01

   Positive

27.4 (5.5)

26.4 (4.5)

.14

   Negative

24.8 (5.7)

23.3 (5.5)

.05

   Disorganized Thoughts

25.0 (5.5)

24.1 (4.2)

.21

   Impulsivity/Hostility

11.0 (3.5)

10.6 (3.4)

.36

   Anxiety/Depression

14.4 (3.6)

13.1 (3.4)

.005

CGI-S mean [SD])

4.8 (0.8)

4.7 (0.7)

.20

Weight, kg (mean [SD])

85.6 (22.2)

84.1 (19.2)

.58

  1. Abbreviations: CGI-S = Clinical Global Impression-Severity; PANSS = Positive and Negative Syndrome Scale; SD = standard deviation.
  2. a Early response = ≥30% reduction from baseline in PANSS Total score at Week 4; later response = ≥40% reduction in PANSS Total score at Week 8.