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Table 1 Baseline Characteristics for Responder Groupsa among patients with chronic schizophrenia treated with olanzapine LAI

From: Early response predicts subsequent response to olanzapine long-acting injection in a randomized, double-blind clinical trial of treatment for schizophrenia

Baseline Characteristics Early
Responders
(n = 137)
Early
Non-responders
(n = 96)
p-value
Age, years (mean [SD]) 40.8 (11.6) 38.8 (11.1) .18
Female gender, (n [%]) 35 (25.6) 30 (31.3) .34
Race (n [%])    .75
   White 81 (59.1) 55 (57.3)  
   African American 47 (34.3) 33 (34.4)  
   Hispanic 8 (5.8) 5 (5.2)  
   Other 1 (0.7) 3 (3.1)  
Age at first schizophrenia episode, years
(mean [SD])
23.7 (7.9) 22.1 (8.7) .15
PANSS scores (mean[SD])    
   Total 102.5 (16.0) 97.5 (12.3) .01
   Positive 27.4 (5.5) 26.4 (4.5) .14
   Negative 24.8 (5.7) 23.3 (5.5) .05
   Disorganized Thoughts 25.0 (5.5) 24.1 (4.2) .21
   Impulsivity/Hostility 11.0 (3.5) 10.6 (3.4) .36
   Anxiety/Depression 14.4 (3.6) 13.1 (3.4) .005
CGI-S mean [SD]) 4.8 (0.8) 4.7 (0.7) .20
Weight, kg (mean [SD]) 85.6 (22.2) 84.1 (19.2) .58
  1. Abbreviations: CGI-S = Clinical Global Impression-Severity; PANSS = Positive and Negative Syndrome Scale; SD = standard deviation.
  2. a Early response = ≥30% reduction from baseline in PANSS Total score at Week 4; later response = ≥40% reduction in PANSS Total score at Week 8.