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Table 3 Symptom severity at Baseline and at Last Observation Carried Forward

From: Database analysis of children and adolescents with Bipolar Disorder consuming a micronutrient formula

  

Bipolar

 

ADHD

 
  

symptom severity (range 0 to 48)

 

symptom severity (range 0 to 9)

 

row #

Data Sample

Baseline

Last Observation Carried Forward

%change from Baseline

effect size

sample size: N =

Baseline

Last Observation Carried Forward

%change from Baseline

effect size

sample size: N =

1

Primary Sample: Bipolar = sum of sub-samples #2 and #3

     
 

Mean

17.8

9.6 ***

-46%

0.78

120

5.0

3.0 *

-40%

0.62

29

 

Median

17.4

7.1

-59%

  

5.0

3.0

-40%

  
 

Std. Deviation

10.1

8.3

   

2.9

2.2

   
 

Baseline-Median Split Sample: split by Baseline bipolar symptom severity

split by Baseline ADHD symptom severity

1 Above

Above Baseline Median:

        
 

Mean

25.1

12.9 ***

-49%

1.21

60

7.5

3.1 ***

-59%

1.72

14

 

Median

24.0

10.9

-54%

  

7.0

3.0

-57%

  
 

Std. Deviation

6.1

9.4

   

1.1

2.7

   

1 Below

Below Baseline Median:

        
 

Mean

9.1

6.4 ***

-30%

0.45

60

2.7

2.9

7%

-0.10

15

 

Median

8.7

5.6

-36%

  

3.0

3.0

0%

  
 

Std. Deviation

4.6

5.4

   

1.9

1.8

   

1 Older

Age 12 or above:

          
 

Mean

17.1

9.3 ***

-46%

0.81

70

4.4

2.2 **

-50%

0.67

15

 

Median

16.0

7.1

-55%

  

4.0

1.4

-65%

  
 

Std. Deviation

10.5

8.2

   

2.4

2.1

   

1 Younger

Age younger than 12:

        
 

Mean

17.1

10.2 ***

-41%

0.73

50

5.7

3.8 *

-33%

0.54

14

 

Median

17.6

6.9

-61%

  

7.0

3.4

-51%

  
 

Std. Deviation

8.6

8.5

   

3.3

2.2

   

1 Male

Male: Mean

17.4

10.3 ***

-41%

0.67

71

4.9

3.0 **

-39%

0.59

21

 

Male: Median

17.0

7.2

-58%

  

5.0

3.0

-40%

  
 

Std. Deviation

8.9

8.8

   

3.1

2.1

   

1 Female

Female: Mean

18.3

8.7 ***

-53%

0.94

49

5.4

3.1

-43%

0.64

8

 

Female: Median

17.8

6.2

-65%

  

6.7

2.5

-63%

  
 

Std. Deviation

9.3

7.5

   

2.5

2.7

   

2

Sub-Sample: Bipolar but not ADHD

        
 

Mean

16.7

9.4 ***

-44%

0.80

91

     
 

Median

15.7

6.6

-58%

       
 

Std. Deviation

9.9

8.3

        

3

Sub-Sample: Bipolar and ADHD

        
 

Mean

18.2

10.3 ***

-43%

0.72

29

5.0

3.0 **

-40%

0.62

29

 

Median

20.0

8.6

-57%

  

5.0

3.0

-40%

  
 

Std. Deviation

9.0

8.3

   

2.9

2.2

   

4

Alternative Sample: ADHD but not bipolar

        
 

Mean

     

6.0

3.2 ***

-47%

1.04

41

 

Median

     

6.7

2.8

-58%

  
 

Std. Deviation

     

2.5

2.6

   
  1. Notes: *** indicates that mean LOCF is significantly different from mean at Baseline, at level p < .001; ** at level p < .01; *at level p < .05
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BMC Psychiatry

ISSN: 1471-244X

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